The liver in Hodgkin ' s disease TABLE I INCIDENCE OF HEPATIC ENLARGEMENT AND INVOLVEMENT WITH HODGKIN S DISEASE IN PATIENTS WITH HODGKIN S DISEASE

Hepatomegaly and abnormal results in liver function tests are frequently encountered in patients during the course of Hodgkin's disease. It is tacitly assumed in many cases that these findings are part of the general disease process. We were impressed, however, by the frequent occurrence of hepatic changes unrelated to the presence of Hodgkin's disease, and by the difficulty in distinguishing Hodgkin's disease involving the liver from other liver disease in these patients. The present study analyses 112 necropsied cases of Hodgkin's disease with clinical or laboratory evidence of liver disease during life, or both, and reviews the literature in an attempt to elucidate this difficult problem.